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This page is dedicated to an overview of publications at the Metabolism Lab and up-to-date article collections related to our research themes.
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- Eimeria infections of plateau pika altered the patterns of temporal Tuesday 29 April 2025 And quickly frozen with liquid nitrogen for storage. After the with parasite-modified energy metabolism patterns. The change in diet from diverse plants in the field to simple
- Effects of tillage methods on soil aggregate nematode community in fluvo-aquic soil area of North China. Thursday 10 April 2025 In small mega-aggregates (2-5 mm), and decreased that of plant-parasitic nematodes matter was dominated by bacteria. Soil organic carbon, total nitrogen content, and
- iocontrol Strategies for Sustainable Management of Root-Knot Nematodes Saturday 21 December 2024 The most damaging plant-parasitic nematodes globally. is the use of plant growth-promoting microbes (PGPM)- and iron, fixing nitrogen, producing phytohormones,
- Effect of soil moisture on nematode abundance and composition is modulated by determinism in community assembly in a savanna Thursday 27 March 2025 Variation in precipitation and microbial biomass carbon diversity was primarily controlled by soil nitrogen and impacted bacterivores and plant parasite diversity. At the
- A REVIEW OF THE EFFECT OF SOME PLANT BACTERIA ON GROUNDNUT PLANT IN NIGERIA Thursday 07 November 2024 These bacteria suppress pathogenic microbes through by fungi, bacteria, and nematodes, thereby contributing to Nitrogen-fixing bacteria are integral to the nitrogen cycle
- Unearthing the hidden dangers by soil borne diseases of nursery plants: A review Wednesday 31 July 2024 As excessive moisture and nitrogen availability can give , apart from viruses and plant parasitic nematodes, soil as insect pests or plantdamaging microorganisms, can
- elatonin as a modulator of MAPK cascade and ROS-RNS feedforward loop during plant pathogen interaction Saturday 27 July 2024 , bacteria, viruses, viroids, phytoplasma, and nematodes, (ROS) and reactive nitrogen species (RNS) levels, and In plants, melatonin metabolism encompasses a series
- Soil Nematodes as an Indicator of the Efficiency of Hydrophytic Treatment Plants with Vertical Wastewater Flow Tuesday 31 December 2024 Plant beds are abundantly populated by bacteria participating in key organic matter decomposition processes and nitrogen to the digestion and metabolism of the bacterial
- Understanding the dynamic Thursday 23 January 2025 (rhizosphere bacteria) and inside plant roots (endophytic bacteria) on both plant development and metabolism through the the movement of nitrogen-fixing bacteria to the
- 3 Omics' Approach to Discern the Functional Diversity of Fungi in Plants Saturday 18 January 2025 Microorganismplant interactions in nitrogen fixation, improve our understanding of plant microbes and their -related grapevine plant woods carbohydrate metabolism (
- Soil biological health assessment based on nematode communities under maize and peanut intercropping Monday 11 November 2024 And plant parasitic nematode abundance, microbial the peak period of interaction between the intercropped ammonium nitrogen content and the nematode enrichment
- Soybean cyst nematode proliferation is slowed by local cyst bacteria Friday 26 July 2024 Soybean is an important food crop also used for biofuel production and nitrogen and that specific microbial communities targeting plant-parasitic nematodes could be
- lant Parasitic Nematodes: A Major Constraint to Pulses Production and Their Management Options$ Friday 10 January 2025 By fixing atmospheric nitrogen through nematodes and promote antagonistic microbial activity. Many biocontrol agents are effective against plant parasitic nematodes
- … sp. 30702 composite chitosan alleviates continuous cropping obstacles in Chinese yam by improving rhizospheric soil microbial environment: A field study in … Saturday 03 August 2024 Plant, yet its cultivation faces increasing challenges, particularly due to pathogenic community, while available nitrogen and root-knot nematodes significantly affect the
- … .. NCHULUS RENIFORMIS AND ASSOCIATED POPULATIONS OF PREDACIOUS AND SAPROPHYTIC ARTHROPODS AND MICROPHAGOUS NEMATODES Tuesday 31 December 2024 In controlling nematode populations, plant growth was of associated microorganisms before experimentation. pots, each at the rate of 108kg nitrogen/ha, while one set
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Phospholipids in plant systems: metabolism, regulation and functional insights
Progress in Lipid Research, volume 101
Sunday 08 February 2026
Phospholipids are essential components of cellular membranes in plants and play important roles in several biological processes including membrane biogenesis, signaling, and stress response. Here, we systematically review the metabolic pathways that coordinate the assembly and degradation of phospholipids, as well as the functional roles of phospho...
Phospholipids are essential components of cellular membranes in plants and play important roles in several biological processes including membrane biogenesis, signaling, and stress response. Here, we systematically review the metabolic pathways that coordinate the assembly and degradation of phospholipids, as well as the functional roles of phospholipids in plant growth. To achieve this, we summarize recent biochemical and physiological studies of key enzymes involved in these pathways, and highlight the regulation of phospholipid metabolism at the transcriptional, post-transcriptional, and post-translational levels. These processes facilitate dynamic adjustments in phospholipid levels in response to environmental stressors and signaling pathways, and are crucial for maintaining phospholipid homeostasis and plant development. In addition, beyond their roles in maintaining the structural integrity of biological membranes, we also discuss crosstalk between phospholipid metabolic pathways, glycolipid production, and lipid droplet formation. Collectively, these insights contribute to a deeper understanding of phospholipid dynamics and their multifunctional roles in plants.
Mevinolin (MEV) modulates terpenoid biosynthesis in ‘Shine Muscat’ grapes by regulating HMGR enzyme
BMC Plant Biology, volume 26
Saturday 31 January 2026
Transcriptome and Metabolome Analysis Reveal Genes Involved in Flavonoid and Terpenoid Biosynthesis in Tectaria coadunata (J.Sm.) C.Chr.
Plant Molecular Biology Reporter, volume 44
Friday 30 January 2026
Broccoli plant elicitor peptide BoPep4 enhances plant salt tolerance by improving glucosinolate metabolism
Plant Science, volume 364
Thursday 29 January 2026
Plant elicitor peptides (Peps), derived from precursor proteins PROPEPs, function as plant peptide hormones regulating abiotic stress tolerance. However, the underlying metabolic mechanisms remain incompletely understood. Here, we show that overexpression of BoPROPEP4 in Arabidopsis and broccoli hairy roots enhances salt toleranc...
Plant elicitor peptides (Peps), derived from precursor proteins PROPEPs, function as plant peptide hormones regulating abiotic stress tolerance. However, the underlying metabolic mechanisms remain incompletely understood. Here, we show that overexpression of BoPROPEP4 in Arabidopsis and broccoli hairy roots enhances salt tolerance, as evidenced by improved phenotypic performance, increased chlorophyll levels, optimized Na⁺/K⁺ ratios, reduced H₂O₂ levels, and elevated antioxidant enzyme activities. Salt stress induces the upregulation of salt-responsive genes in transgenic lines and triggers the in vivo cleavage of BoPROPEP4 into the mature peptide BoPep4. Transcriptomic analysis reveals that BoPep4 modulates glucosinolate metabolism in broccoli, leading to increased accumulation of aliphatic and indole glucosinolates and their bioactive derivatives sulforaphane and indole-3-carbinol under salt stress. Furthermore, exogenous BoPep4 application to salt-stressed broccoli upregulates the expression of genes involved in glucosinolate biosynthesis and degradation, increases GSH content via sulfur reallocation from glucosinolate degradation, and boosts antioxidant enzyme activities. Genetic validation through virus-induced gene silencing of BoPROPEP4 and BoPEPR2 in broccoli demonstrates reduced glucosinolate levels and compromised salt tolerance. In Arabidopsis, the protective effect of BoPep4 against salinity is diminished in glucosinolate-degradation mutants (pen2 and tgg1/2), highlighting the importance of functional glucosinolate metabolism in BoPep4-mediated salt adaptation. This study uncovers a novel metabolic mechanism underlying peptide-mediated salt tolerance and provides a potential approach for enhancing crop salt tolerance.
Expansion of the plant-parasitic nematode RNA viruses: Unprecedented diversity, intron-bearing viruses, and cross-kingdom evolutionary links
Npj Biofilms and Microbiomes, volume 12
Wednesday 28 January 2026
Terpenoid-Based Inhibition of SQLE: Mechanistic Computational and Experimental Insights into Targeting Cholesterol Biosynthesis
Journal of Computational Biophysics and Chemistry, volume 25, pages 853-874
Tuesday 27 January 2026
The effects of cholesterol supplementation in full-plant protein diets derived from different lipid sources on liver and intestinal health, bile acid metabolism in largemouth bass (Micropterus salmoides)
Aquaculture Reports, volume 46
Monday 26 January 2026
A review of transcriptional control and adaptive functions in terpenoid biosynthesis: Focus on MYB regulatory networks
Plant Science, volume 364
Sunday 25 January 2026
Terpenoids constitute one of the most chemically diverse and functionally significant classes of plant secondary metabolites, involved in growth regulation, environmental responsiveness, and interactions with biotic factors. In fruit-bearing plants, terpenoids not only contribute to aromatic traits that affect flavor and commerci...
Terpenoids constitute one of the most chemically diverse and functionally significant classes of plant secondary metabolites, involved in growth regulation, environmental responsiveness, and interactions with biotic factors. In fruit-bearing plants, terpenoids not only contribute to aromatic traits that affect flavor and commercial value but also serve as natural agents of defense. The biosynthesis of terpenoids proceeds through two evolutionarily conserved metabolic routes: the cytosolic mevalonate (MVA) pathway and the plastid-localized methylerythritol phosphate (MEP) pathway. At the final stage of these pathways, terpene synthases (TPSs) catalyze the formation of structurally diverse terpenoid compounds and are considered key enzymes in terpenoid biosynthesis. Recent genomic and functional studies have revealed both the expansion and diversification of TPS gene families across various horticultural species and the increasing complexity of their transcriptional regulation. This has led to growing interest in the transcriptional regulatory networks that coordinate terpenoid metabolism. Among these regulators, MYB transcription factors have emerged as central components, which can directly activate or repress the expression of TPS and other pathway genes and often function through cooperative or antagonistic interactions with other transcription factor families. Additionally, MYB factors respond to various environmental and endogenous signals such as light, hormones, and nutrient availability, positioning them as crucial regulators in adaptive terpenoid metabolic control.
Integration of transcriptomics and metabolomics provides insights into secondary cell wall deposition and terpenoid biosynthesis during stem development in Camphora officinarum
BMC Genomics, volume 27
Saturday 24 January 2026
Construction and analysis of a cell factory for terpenoid biosynthesis in Pichia pastoris via metabolic engineering and metabolomics
Synthetic and Systems Biotechnology, volume 11, pages 68-75
Friday 23 January 2026
Terpenoids are widely distributed in nature and have various applications in health products, pharmaceuticals, and fragrances. Despite the tremendous potential of terpenoids, traditional production methods such as plant extraction and chemical synthesis face challenges in meeting current market demands. With the developments in synthetic biology an...
Terpenoids are widely distributed in nature and have various applications in health products, pharmaceuticals, and fragrances. Despite the tremendous potential of terpenoids, traditional production methods such as plant extraction and chemical synthesis face challenges in meeting current market demands. With the developments in synthetic biology and metabolic engineering, it has become feasible to construct efficient microbial cell factories for large-scale production for terpenoids. In this work, using the yeast Pichia pastoris as the host cell, a "plug-and-play" cell factory for universal terpenoid production was constructed by enhancing the expression of the MVA pathway for common precursor synthesis and reducing branch pathway diversion strategies. We have successfully and efficiently synthesized β-elemene, β-farnesene, (+)-valencene, (−)-α-bisabolol by this cell factory. Furthermore, by analyzing metabolites in different engineered strains in terms of system biology, it was discovered that an increase in key protein copy numbers enhanced the synthesis of arginine and other metabolic pathways. The robustness of the strains and the tightly regulated metabolic network constrain rational metabolic engineering transformations. These data provide important clues for the modification and optimization of production strains.
Stress-associated proteins (SAPs): Molecular hubs connecting plant stress, development, and metabolism
Plant Science, volume 364
Thursday 22 January 2026
Stress-associated proteins (SAPs) are a versatile class of proteins extensively found in microbes, plants, and animals. They play a pivotal role in plant responses to environmental challenges such as drought, salinity, heat, and pathogen infection, thereby enhancing stress tolerance and safeguarding agricultural yields. Current r...
Stress-associated proteins (SAPs) are a versatile class of proteins extensively found in microbes, plants, and animals. They play a pivotal role in plant responses to environmental challenges such as drought, salinity, heat, and pathogen infection, thereby enhancing stress tolerance and safeguarding agricultural yields. Current research has largely focused on the stress-responsive functions of SAPs, while the connections between their diverse roles and practical applications remain less synthesized. To advance the understanding of the SAPs family and facilitate for future research into stress-tolerant crop breeding aimed at reducing yield losses, this paper comprehensively examines the classification, structural traits, molecular mechanisms, and application potential of SAPs in stress regulation.
Multilayered regulation of TORC1 signaling by Ait1, Gcn2, and SEAC/GATOR during nitrogen limitation and starvation
Nature Communications, volume 17
Wednesday 21 January 2026
Identification of plant-parasitic nematode genera in turfgrass using deep learning algorithms
Scientific Reports, volume 16
Tuesday 20 January 2026
Metabolic reprogramming of abscisic acid-producing strain Botrytis cinerea TB-31 toward terpenoid biosynthesis using a CRISPR/Cas9 ribonucleoprotein system
Synthetic and Systems Biotechnology, volume 12, pages 238-254
Monday 19 January 2026
Compared with conventional microbial hosts, filamentous fungi have distinct advantages for the industrial-scale biosynthesis of high-value chemical compounds. However, current research on strain engineering and fermentation optimization strategies for synthetic biology applications is limited in filamentous fungi, especially in industrial productio...
Compared with conventional microbial hosts, filamentous fungi have distinct advantages for the industrial-scale biosynthesis of high-value chemical compounds. However, current research on strain engineering and fermentation optimization strategies for synthetic biology applications is limited in filamentous fungi, especially in industrial production strains. In this study, we established a CRISPR/Cas9-based gene editing system in Botrytis cinerea strain TB-31, an important filamentous fungal platform for the study of the biosynthesis and regulation of the sesquiterpenoid abscisic acid (ABA). This system enables efficient single- and multigene knockout, large-fragment deletion, and heterologous protein expression. Among the engineered mutant strains, the △bcaba1234 strain with complete ablation of the ABA biosynthetic gene cluster (BGC) demonstrated significant metabolic flux rewiring, redirecting cellular resources toward terpenoid precursor biosynthesis; this metabolic reprogramming proves pivotal for high-value terpenoid biosynthesis. This study not only establishes an efficient genome editing tool for the ABA-producing strain B. cinerea TB-31 but also provides a foundation for its development as a new potential terpenoid-producing chassis strain.
The plant lipid contactome: emerging roles of inter-organelle contact sites in lipid metabolism
Progress in Lipid Research, volume 101
Sunday 18 January 2026
Membrane contact sites (MCSs) are fundamental hubs of inter-organelle communication that mediate the non-vesicular exchange of lipids, ions, and metabolites, thereby sustaining cellular homeostasis. In plants, the “contactome”—the dynamic network of all membrane contact sites—has evolved distinctive features to accommodate the requirements ...
Membrane contact sites (MCSs) are fundamental hubs of inter-organelle communication that mediate the non-vesicular exchange of lipids, ions, and metabolites, thereby sustaining cellular homeostasis. In plants, the “contactome”—the dynamic network of all membrane contact sites—has evolved distinctive features to accommodate the requirements of a sessile, photosynthetic lifestyle and the presence of plastids. Within this network, the endoplasmic reticulum (ER) functions as a central hub for lipid biosynthesis and distribution, forming functionally important contacts with multiple organelles. Recent advances in high-resolution imaging, lipidomics, and molecular genetics are beginning to uncover the complexity of these inter-organelle connections and their contribution to lipid homeostasis in plants. This review summarizes current knowledge of the plant contactome, with a focus on lipid transfer proteins and lipid-modifying enzymes that maintain lipid balance during organelle biogenesis, plant development, and stress adaptation. Plant lipid transfer at membrane contact sites can be broadly divided into two mechanistic modes: precision-regulated “shuttles,” exemplified by the Ca2+-dependent SYT1-mediated diacylglycerol transfer at ER–plasma membrane interfaces, and high-capacity lipid transfer mechanisms, such those mediated by ATG2, that support rapid lipid flux during autophagosome biogenesis. Knowledge of lipid metabolism at plant membrane contact sites is still in its initial stages, and many of the underlying mechanisms remain unexplored. Major challenges include understanding how these sites integrate stress responses, metabolic fluxes, and organelle dynamics. Addressing these questions will be essential to unravel the unique aspects of plant lipid biology and may open opportunities for improving stress resilience and metabolic engineering in crops.
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